Dr Mercola Interviews Dr Villeponteau the Formulator of Stem Cell 100

Dr Bryant Villeponteau the formulator of Stem Cell 100 and other Life Code nutraceuticals was recently interviewed by Dr Mercola who owns the largest health web site on the internet. Dr. Villeponteau is also the author of Decoding Longevity an new book which will be released during December. He is a leading researcher in novel anti-aging therapies involving stem cells an area in which he has been a pioneer for over three decades.

Stem cell technology could have a dramatic influence on our ability to live longer and replace some of our failing parts, which is the inevitable result of the aging process. With an interest in aging and longevity, Dr. Villeponteau started out by studying developmental biology. If we could understand development, we could understand aging, he says. Later, his interest turned more toward the gene regulation aspects. While working as a professor at the University of Michigan at the Institute of Gerontology, he received, and accepted, a job offer from Geron Corporation a Bay Area startup, in the early 90s.

They were working on telomerase, which I was pretty excited about at the time. I joined them when they first started, he says. We had an all-out engagement there to clone human telomerase. It had been cloned in other animals but not in humans or mammals.

If you were to unravel the tip of the chromosome, a telomere is about 15,000 bases long at the moment of conception in the womb. Immediately after conception, your cells begin to divide, and your telomeres begin to shorten each time the cell divides. Once your telomeres have been reduced to about 5,000 bases, you essentially die of old age.

What you have to know about telomerase is that it’s only on in embryonic cells. In adult cells, it’s totally, for the most part, turned off, with the exception of adult stem cells, Dr. Villeponteau explains. Adult stem cells have some telomerase not full and not like the embryonic stem cells, but they do have some telomerase activity.

Most of the research currently being done, both in academia and industrial labs, revolves around either embryonic stem cells, or a second type called induced pluripotent stem cells (iPS). Dr. Villeponteau, on the other hand, believes adult stem cells are the easiest and most efficient way to achieve results.

That said, adult stem cells do have their drawbacks. While they’re your own cells, which eliminates the problem of immune-related issues, there’s just not enough of them. Especially as you get older, there are fewer and fewer adult stem cells, and they tend to become increasingly dysfunctional too. Yet another hurdle is that they don’t form the tissues that they need to form…

To solve such issues, Dr. Villeponteau has created a company with the technology and expertise to amplify your adult stem cells a million-fold or more, while still maintaining their ability to differentiate all the different cell types, and without causing the cells to age. Again, it is the adult stem cells ability to potentially cure, or at least ameliorate, many of our age-related diseases by regenerating tissue that makes this field so exciting.

Dr Villeponteau believes you can add many years, likely decades, to your life simply by eating right, exercising (which promotes the production of muscle stem cells, by the way) and living an otherwise clean and healthy lifestyle. Extreme life extension, on the other hand, is a different matter.

His book, Decoding Longevity, covers preventive strategies to prolong your life, mainly diet, exercise, and supplements. A portion of the book also covers future developments in the area of more radical life extension, such as stem cell technology.

If you would like to read the entire interview here is a link to the text version:

Click here for more information about Stem Cell 100

Transcript of Interview With Dr. Bryant Villeponteau by Dr. Joseph Mercola

Aging Reversed / ABC News

Now researchers have found a way not just to stop, but, reverse the aging process. The key is something called a telomere. We all have them. They are the tips or caps of your chromosomes. They are long and stable in young adults, but, as we age they become shorter, damaged and frayed. When they stop working we start aging and experience things like hearing and memory loss.

In a recent study published in the peer reviewed journal Nature scientists took mice that were prematurely aged to the equivalent of 80-year-old humans, added an enzyme and essentially turned their telomeres back on. After the treatment they were the physiological equivalent of young adults. You can see the before and after pictures in the videos above. Brain function improved, their fertility was restored it was a remarkable reversal of the aging process. In the top video the untreated mouse shows bad skin, gray hair and it is balding. The mouse with it’s telomeres switched back on has a dark coat color, the hair is restored and the coat has a nice healthy sheen to it. Even more dramatic is the change in brain size. Before treatment the aged mice had 75% of a normal size brain like a patient with severe Alzheimers. After the telomeres were reactivated the brain returned to normal size. As for humans while it is just one factor scientists say the longer the telomeres the better the chances for a more graceful aging.

The formal study Telomere dysfunction induces metabolic and mitochondrial compromise was published in Nature.

Additional information published by Harvard can be found in the following articles.

Scientists Find Root Molecular Cause of Declining Health in the Old

Decoding Immortality – Smithsonian Channel Video about the Discovery of Telomerase

While scientists are not yet able to accomplish the same results in humans we believe we have developed a nutraceutical to help prolong youth and possibly extend life until age reversal therapy for humans becomes available.

Stem Cells Secret’s of 115 Year Old Woman

New evidence that adult stem cells are critical to human aging has recently been published on a study done on a super-centenarian woman that lived to be 115 years. At death, her circulating stem cell pool had declined to just two active stem cells from stem cell counts that are typically more than a thousand in younger adults. Super-centenarians have survived all the normal diseases that kill 99.9% of us before 100 years of age, so it has been a mystery as to what actually kills these hardy individuals. This recent data suggest that stem cell decline may be the main contributor to aging. If so, stabilizing stem cells may be the best thing one can do to slow your rate of aging.

There are many theories of aging that have been proposed. For example, damage to cells and tissues from oxidative stress has been one of the most popular fundamental theories of aging for more than half a century. Yet antioxidant substances or genes that code antioxidant enzymes have proven largely ineffective in slowing aging when tested in model animals. Thus, interest by scientists has shifted to other hypotheses that might provide a better explanation for the slow declines in function with age.

Stem cells provide one such promising mechanism of aging. Of course, we all know that babies are young and vigorous, independent of the age of their parents. This is because adults have embryonic stem cells that can generate young new cells needed to form a complete young baby. Indeed, these embryonic stem cells are the product of continuously evolving stem cell populations that go back to the beginning of life on earth over 3.5 billion years ago!

In adults, the mostly immortal embryonic stem cells give rise to mortal adult stem cells in all the tissues of the body. These adult stem cells can regenerate your cells and tissues as they wear out and need replacement. Unfortunate, adult stem cells also age, which leads to fewer cells and/or loss of function in cell replacement. As functional stem cells decline, skin and organs decline with age.

Blood from world’s oldest woman suggests life limit

Time Magazine: Long-Life Secrets From The 115-Year-Old Woman

Somatic mutations found in the healthy blood compartment of a 115-yr-old woman demonstrate oligoclonal hematopoiesis

Abstract
The somatic mutation burden in healthy white blood cells (WBCs) is not well known. Based on deep whole-genome sequencing, we estimate that approximately 450 somatic mutations accumulated in the nonrepetitive genome within the healthy blood compartment of a 115-yr-old woman. The detected mutations appear to have been harmless passenger mutations: They were enriched in noncoding, AT-rich regions that are not evolutionarily conserved, and they were depleted for genomic elements where mutations might have favorable or adverse effects on cellular fitness, such as regions with actively transcribed genes. The distribution of variant allele frequencies of these mutations suggests that the majority of the peripheral white blood cells were offspring of two related hematopoietic stem cell (HSC) clones. Moreover, telomere lengths of the WBCs were significantly shorter than telomere lengths from other tissues. Together, this suggests that the finite lifespan of HSCs, rather than somatic mutation effects, may lead to hematopoietic clonal evolution at extreme ages.

Ingredients in Pills Can Lead to Adverse Reactions

pillsA recent study conducted by the Brigham and Women’s Hospital and the Massachusetts Institute of Technology have discovered that a large majority of some of the most frequently prescribed medications in the U.S. contain at least one “inactive ingredient” that could cause adverse reactions.

Inactive ingredients are added to medications to improve taste, absorption, shelf life and a variety of other characteristics of a pill. The study team found that over 90 percent of all oral medications they tested contained an ingredient which can lead to gastrointestinal symptoms and other allergic reactions in sensitive people.

The inactive ingredients include peanut oil, lactose, chemical dyes and gluten. These added ingredients present a challenge to clinicians who want to make sure they are prescribing a medication that does not cause an allergic or adverse reaction. The study actually was inspired by a real life situation where an individual with celiac disease was prescribed a medication that contained gluten.

The team collaborated with a biochemical data scientist and an internal medicine resident and others to analyze data of inactive ingredients found in 42,052 oral medications all of which contained more than 354,597 inactive ingredients. Inactive ingredients are defined as any substance that is added to a pill’s formulation but are not expected or intended to have any direct therapeutic or biological effect.

Inactive ingredients have been tested for safety at population levels. However, scattered case reports have shown that inactive ingredients can cause problems for individuals with intolerances and allergies.

The team notes that the data set is complex. There are hundreds of different versions of capsules or pills that deliver the exact same medication but use a different combination of inactive ingredients. This indicates how convoluted the choices of inactive ingredients is. But it also suggests that there is an untapped opportunity to specifically choose the most appropriate version of a medication for someone with unusual sensitivities.

The research team discovered a total of 38 inactive ingredients that have been described in literature to cause adverse symptoms after oral exposure. At least 92.8 percent of medications analyzed contained at least one of these ingredients. About 45% contained lactose, about 33% contained a food dye, and about .08% contained peanut oil.

While the content of a particular inactive ingredient may be too low to lead to an adverse reaction in most people, someone with an allergy or intolerance could have a reaction. These doses may be low, however it isn’t known what the threshold is for individuals to react to them. This pushes scientists to think about precision care and the role of legislation and regulation when it comes to medication labels that contain an inactive ingredient that can cause adverse reactions.

To view the original scientific study click below.

“Inactive” ingredients in oral medications

Youthful Blood Cells Rejuvenate Brain

brain rejuvinationA new study has shown that by transplanting the bone marrow of young lab mice into older lab mice, cognitive decline was prevented. The younger blood cells preserved memory and learning abilities in the senior mice. The findings have supported an emerging model which attributes decline in cognitive skills at least in part to the aging of blood cells which are produced in bone marrow.

Previous studies have shown the results, however, it has not been well understood how it happens. The new research which was conducted by Cedars Sinai Medical Center, suggests that one explanation lies in specific properties of the younger blood cells.

For the study, 18 month old lab mice received bone marrow transplants from either mice their own age or 4 month old mice. At six months, both groups underwent a variety of standard lab tests including activity level and learning and working and spatial memory. The mice that received the young bone marrow transplants outperformed the mice who received the old bone marrow transplant. They also outperformed a control group of older mice that did not get any transplants.

The team then examined the hippocampus, a region in the brain which is associated with memory. The mice who received the young bone marrow transplant retained more synapses (connections) between neurons in the hippocampus than did the recipients of the older bone marrow. Synapses are important to brain health.

Additional tests indicated a possible explanation for the missing synapses. They found that the blood cells made by the young bone marrow reduced the activation of microglia. Microglia are a type of immune cell found in the brain. They support neuron health but can also become overactive and take part in disconnection of synapses. Fewer overactive microglia allows neurons to remain healthy and more synapses to survive.

With the increase in more elderly people in populations and an increase in neurodegenerative diseases, there will be a huge burden on health systems. If continued research confirms similar processes in humans, the findings could provide pathways for creating therapies to slow the progression of these types of diseases. However, translating the results if confirmed in human samples into possible treatment plans is challenging. Currently, bone marrow transplants are not feasible for this use.

The team is currently working on creating personalized young blood stem cells through stem cell technology. It is hoped that these cells might be used to help replace an individuals own aging blood cells to help prevent cognitive decline and even neurodegenerative diseases. Below is a link to the original scientific study.

Young bone marrow transplantation preserves learning and memory in old mice.