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Stem Cell 100 provides Telomere Support
Recent research indicates that the ends of chromosomes (i.e. telomeres) play a key role in aging. Telomeres shorten as we age, leading to aging at the cellular level. Telomerase is the key antiaging enzyme that repairs the ends of chromosome (telomeres) by maintaining telomere length. Harvard scientists have shown that the fundamental cause of age-related health decline is linked to telomerase. Mice without telomerase prematurely age, whereas activating telomerase in these old mice brings back youthful looks and function. Many scientists believe that telomerase mediated reversal of age-related disorders may also work in humans. It has been shown that healthy diet and exercise, which lengthen life, increase telomerase activity and telomere length1. Moreover, people with shorter telomeres have higher mortality rates (P < 0.009)2, and have higher rates of Alzheimer’s3,4, cardiovascular disease5, diabetes6, and renal disease7.
Stem cells are the main class of cells in humans that have detectable telomerase activity. Unfortunately, telomerase activity in human stem cells is typically insufficient to maintain needed function with age. Stem Cell 100 increases telomerase activity in stem cells via the resveratrol analog pterostilbene, which is a major active component in Stem Cell 100. Pterostilbene is a highly potent natural analog of resveratrol with greatly improved oral adsorption and metabolic stability with better activity levels. Resveratrol has been shown to activate telomerase in human adult stem cells in independent studies8,9,10. It also activates the WRN helicase gene that repairs telomeres8, whereas low activities of the WRN gene lead to the premature aging disease known as Warner syndrome. Unfortunately, resveratrol has a 14 min half life in the body and thus is not nearly as effective as its long lasting analog pterostilbene. We have verified that pterostilbene is indeed active in stimulating telomerase.
1. Ornish D, Lin J, Daubenmier J, et al. Increased telomerase activity and comprehensive lifestyle changes: a pilot study. Lancet Oncol. Nov 2008;9(11):1048-1057.
2. Honig LS, Schupf N, Lee JH, Tang MX, Mayeux R. Shorter telomeres are associated with mortality in those with APOE epsilon4 and dementia. Ann Neurol. Aug 2006;60(2):181-187.
3. Jenkins EC, Ye L, Gu H, et al. Shorter telomeres may indicate dementia status in older individuals with Down syndrome. Neurobiol Aging. May 2010;31(5):765-771.
4. Franco S, Blasco MA, Siedlak SL, et al. Telomeres and telomerase in Alzheimer’s disease: epiphenomena or a new focus for therapeutic strategy? Alzheimers Dement. Jul 2006;2(3):164-168.
5. Maubaret CG, Salpea KD, Jain A, et al. Telomeres are shorter in myocardial infarction patients compared to healthy subjects: correlation with environmental risk factors. J Mol Med. Aug 2010;88(8):785-794.
6. Zee RY, Castonguay AJ, Barton NS, Germer S, Martin M. Mean leukocyte telomere length shortening and type 2 diabetes mellitus: a case-control study. Transl Res. Apr 2010;155(4):166-169.
7. Wills LP, Schnellmann RG. Telomeres and telomerase in renal health. J Am Soc Nephrol. Jan 2011;22(1):39-41.
8. Uchiumi F, Watanabe T, Hasegawa S, Hoshi T, Higami Y, Tanuma S. The effect of resveratrol on the werner syndrome RecQ helicase gene and telomerase activity. Curr Aging Sci. Feb 2011;4(1):1-7.
9. Xia L, Wang XX, Hu XS, et al. Resveratrol reduces endothelial progenitor cells senescence through augmentation of telomerase activity by Akt-dependent mechanisms. Br J Pharmacol. Oct 2008;155(3):387-394.
10. Pearce VP, Sherrell J, Lou Z, Kopelovich L, Wright WE, Shay JW. Immortalization of epithelial progenitor cells mediated by resveratrol. Oncogene. Apr 10 2008;27(17):2365-2374.
