Memex® 100+ for Better Memory and Neural Health plus Anti-Aging Support for the Whole Body


Memex 100+ Options




Memex® 100+ is our third generation, patent-pending nutraceutical supplement that promotes anti-aging pathways for the whole body with support for memory, thinking, and coordination.

As people age they typically respond, remember, and move slower than do younger people. Memex® 100+ has 21 active components that act on longevity genes to slow or reverse the decline in youthful levels of neural function, memory, and coordination as you age.

Developed by experts in the anti-aging field, Memex® 100+ was created using genetic data and biotechnology to select natural compounds which were then rigorously tested in both animal and human studies to identify a mix of substances that synergistically improved cell and neural function.

Memex 100+®, Stem Cell 100® and Stem Cell 100+® are all versions of the same nutraceutical. Memex® 100+ contains overall anti-aging ingredients plus support for memory and brain health. In addition to our highly effective proprietary astragalus which is in Stem Cell 100®, Stem Cell 100+® and Memex® 100+, we have added astragaloside IV to Memex® 100+ making it an even more potent anti-aging nutraceutical. We recommend you select one of the 3 depending upon which fits your personal needs. All 3 act on many stem cell and anti-aging mechanisms.

The function of the neural system declines with age. Older people typically respond, remember, and move slower than do younger people. The question is: Can this normal neural decline with age be slowed or even stopped? At Life Code, we believe that our new herbal supplement Memex® 100+ offers the potential to slow the decline in youthful levels of neural function, memory, and coordination as you age. This belief is based on the science and research behind Memex® 100+TM.

In the Figure below, we compare crawl times for Drosophila groups with a Normal Group (dashed blue line) or with a Weakened Group (solid blue line) neural function. The crawl times were measured in seconds that the Drosophila took to crawl from the bottom of a test tube to the top as a function of age. As expected, all Drosophila groups take longer to crawl up the side of the tube as a function of increasing age. Just like humans, Drosophila move slower with age. One can also see that the Weakened Group has much slower crawl times as a function of age. However, if we treat the Weakened Group with Memex® 100, the Memex-treated Weakened Group (solid red line) had nearly as fast crawl times at each age as did the Normal Control Group. These assays are significant, as the plotted lines are the averages of 200 individuals for each of the 3 groups (100 individuals of each sex).

Drosophila Crawl Test with Memex

The above results are dramatic and show that Memex® 100+ is potent in normalizing neural function in Drosophila. In addition most of the individual components in Memex® 100+ have shown efficacy in improving human neural functions in studies published in peer reviewed journals.

Harness the Power of Your Neural Stem Cells

All the organs and differing tissues of the body appear to have adult stem cells available for regenerating cells in case of injury or disease. It was recently discovered that even brain neurons (previously thought to be non-dividing and irreplaceable in adults) have their own reservoirs of adult stem cells for regeneration. Unfortunately, as we age most adult stem cell populations either decline in number and/or lose the ability to differentiate into functional tissue-specific cells. For example, in many organs old folks have only half the number of stem cells found in young people. Thus, adult stem cells become more and more dysfunction with age, which progressively increases organ and tissue dysfunction with age. Memex® 100+ offers a way to receive some of the benefits of stem cell therapy today by improving the effectiveness of your own adult stem cells.

The Many Benefits of Memex® 100+

  1. Better Memory, Cognition, and Coordination [see above graph]
  2. Adult stem cell rejuvenation [1-4, 48-49]
  3. Promotes stem cell self-renewal [55]
  4. A healthy cardiovascular system [5-8]
  5. Healthy blood glucose levels for those already in the normal range [9-13]
  6. Healthy blood pressure levels for those already in the normal range [14-15]
  7. Healthy cholesterol levels for those already in the normal range [9, 16-17]
  8. Younger looking skin [18-24]
  9. Better learning and focus [25-30]
  10. More endurance with vigorous exercise [31-35]
  11. A healthy immune system [31-32, 36-39]
  12. Healthy breasts, colon, pancreas, and prostate [40-46]
  13. Increases M-cholinergic receptor density in senile rats [50]
  14. Promotes cyto-protective autophagy [51]
  15. Has neuro-protective effects with selective binding to glutamate receptors [52-54]

The statements above have not been reviewed by the FDA. Memex® 100+ is not a preventive or treatment for any disease.

Supplement Facts

Memex® 100 is a Patent-Pending Life CodeTM Nutraceutical.

All Life CodeTM products are GMP and nutraceutical grade providing the best of science along with the balance of nature.


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Memex 100+TM Formulation and Use

Serving Size: 3 capsules

Servings Per Container: 30

Recommended Use: Typical usage of Memex® 100+ is tthree capsules per day, preferably at meal times. Since Memex 100+TM is a potent formulation, do not take more than three capsules per day or two capsules of Memex® 100+ and one capsule of Stem Cell 100TM Two capsules per day of Memex® 100+ may be sufficient for those below 110 pounds.

Recommended Users: Anyone from ages 22 and up could benefit from Memex® 100+. Those in their 20s and 30s will like the boost in endurance during sports or exercise, while older users will notice better energy, memory, and coordination.

Active Ingredients: Memex® 100+ is made using a patent-pending combination of natural ingredients. The herbal components are highly extracted natural herbs that are standardized for active components that promote neuronal function, adult stem cells, and help maintain a healthy level of inflammation:

1) Astragalus membranaceus root is one of the main essential components. In traditional Chinese medicine Astragalus is considered a true tonic that can strengthen debilitated patients and increase resistance in general. Modern herbal treatments with Astragalus membranaceus root (often in concert with other herbs) are used to enhance immunity and to help in wound healing. Astragalus contains several compounds that are active on genes that we and others have identified to promote longevity and neural function. For example, mTOR (mammalian Target of Rapamycin) is inhibited by astragalus extracts. The mTOR protein is involved in cell autophagy (the cellular waste system) and mTOR inhibition is reported to extend lifespan in mice and flies. As long lived non-dividing cells, neurons are dependent on healthy levels of cell autophagy. Astragalus also inhibits Microtubule Star (PP2A), which is a protein phosphatase that alters tau phosphorylation levels and can affect memory and brain function. Microtubule Star is strongly linked to longevity and neuronal function in our genetic and machine learning screens.

2) Bacopa Monnieri has been used for centuries in Ayurvedic medicine, either alone or in combination with other herbs, as a memory and learning enhancer, sedative, and anti-epileptic. It grows in wet tropical environments, and, under its common English name of water hyssop, is a popular aquarium plant.

3) Vaccinium uliginosum has positive effects on increasing the insulin sensitivity pathway and reducing the inflammatory factors TNF-alpha and the prostaglandin PGE2. The herb has a history as a medicinal in Chinese traditional medicine to treat diabetes, bladder problems, and swelling of the lining of the stomach and intestines. The extracts of Vaccinium uliginosum berries are highly enriched for their flavonoids (the active ingredients).

4) CoQ10 as Ubiquinone is involved in energy production by the mitochondria in every cell in the body including the brain. CoQ10 is a coenzyme that is ubiquitous in animals and most bacteria (hence the name ubiquinone). This fat-soluble substance, which resembles a vitamin, is present in all respiring eukaryotic cells, primarily in the mitochondria. It is a component of the electron transport chain and participates in aerobic cellular respiration, which generates energy in the form of ATP. Ninety-five percent of the human body’s energy is generated this way. Therefore, those organs with the highest energy requirements—such as the brain, heart, liver, and kidney—have the highest CoQ10 concentrations.

5) Silybum marianum is standardized for Silymarins, which are a complex mix of related Silibins known to promote healthy liver function. Silymarin has been shown to stimulate neurons and immunity [19,20] and is reported to slow aging of blood vessel endothelial cells by increasing telomerase activity 3-fold and reducing the number of senescent cells [21]. Life Code? uses a high quality proprietary S. marianum extract standardized for 95% Silymarins that generates some three times higher levels of survival in Drosophila Stress test experiments.

6) Scutelloria baicalensis also known as Chinese skullcap, has been widely used as a medicinal plant in China for thousands of years, where the preparation from its roots is called Huang-Qin. Flavones such as baicalin, wogonoside and their aglycones baicalein wogonin are the major bioactive compounds extracted from the root of S. baicalensis. These flavones have been reported to have many nutraceutical functions.

7) Fisetin like other polyphenols such as resveratrol, is a sirtuin-activating compound and has been shown in laboratory studies to extend the life of simple organisms like yeast, worms, and flies. It has been shown to be an effective senolytic agent in wild-type mice, with effects of increased lifespan, reduced senescence markers in tissues, and reduced age-related effects. A clinical trial in the U.S. is currently underway as of October 2018 to show effectiveness in humans. In studies conducted on cells in a laboratory, fisetin inhibits the activity of many cytokines. It has also been shown in lab studies to upregulate glutathione, an endogenous antioxidant. Fisetin also has direct activity as a reducing agent, chemically reacting with reactive oxygen species to neutralize them. Based on lab studies, it appears that fisetin lodges in cell membranes and prevents oxidative damage to lipids in the cell membrane. Fisetin, like other flavonoids, has a planar structure, with multiple carbon rings. Fisetin is able to scavenge free radicals as a result of its electron donating capacity, which is due to the presence of two hydroxyl groups on one ring and a hydroxyl group on another ring.

8) Flavonoids and oligo-proanthocyanidins (OPCs) extracted from Pine Bark, which reduce oxidative stress, protect DNA, and help maintain healthy levels of exercise and age related inflammation.

9) Berberine is a natural polyphenolic compound that is found in the Chinese herb Rhizoma coptidis and many other medicinal plants. Berberine is an essential component, as it interacts with neural proteins like tau and amyloid proteins and the neurotransmitter acetylcholine. These pathways are strongly linked to longevity in our genetic and machine-learning screens and to neuronal function though the current literature.

10) Ginger belongs to the family Zingiberaceae. It originated in South-East Asia and then used in many countries as a spice and condiment to add flavor to food. The rhizome of ginger has also been used in traditional herbal medicine. The health-promoting perspective of ginger is attributed to its rich phytochemistry. Jolad et al. grouped fresh ginger into two wide range categories, i.e. volatiles and non-volatiles. Volatiles include sesquiterpene and monoterpenoid hydrocarbons providing the distinct aroma and taste of ginger. On the contrary, non-volatile pungent compounds include gingerols, shogaols, paradols, and zingerone. It has anti-oxidative properties for controlling the process of aging. Generation of free radicals or reactive oxygen species (ROS) during metabolism beyond the antioxidant capacity of a biological system results in oxidative stress and in the aging process. The bioactive molecules of ginger like gingerols have shown antioxidant activity in various modules.

11) Apigenin is another important plant-based flavonoid that is used in Chinese Traditional Medicine. Apigenin decreases cell death by reducing NF-kabbaB, Prostaglandin E2, TNF-alpha, iNOS, COX-2, and Interleukin-1beta. Apigenin is neuroprotective by increasing the numbers of surviving neurons that result from head or cellular trauma. Apigenin also supports mood by lowering cortisol levels and promoting sleep. Brain function is also supported by improving memory and learning.

12) Alpha-Lipoic Acid regenerates other antioxidants. It is a potent reducing agent with the capacity to reduce the oxidized forms of several important antioxidants, including vitamin C, CoQ10, and glutathione. Alpha Lipoic Acid has been shown in animal models to chelate excess metals such as free iron and copper to inhibit excess accumulation. Alpha Lipoic Acid has been found to increase glutathione levels in cultured cells and in the tissues of aged animals fed ALA. Glutathione is an important intracellular antioxidant that also plays a role in the detoxification and elimination of toxins. Studies in rodents have found that glutathione synthesis and tissue glutathione levels are significantly lower in aged animals compared to younger animals, leading to decreased ability of aged animals to respond to oxidative stress or toxin exposure. Research suggests that LA may increase glutathione synthesis in aged rats. Alpha Lipoic Acid is an essential cofactor for several mitochondrial enzyme complexes that catalyze critical reactions related to energy production and the catabolism (breakdown) of a-keto acids and amino acids Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are highly reactive compounds with the potential to damage DNA, proteins, and lipids (fats) in cell membranes. It can directly scavenge (neutralize) physiologically relevant ROS and RNS

13) L-Theanine is a natural amino acid from Camellia sinesis that reduces mental stress and inflammation while improving cognition and protecting brain cells from ischemic or toxic injury. L-theanine alters novel longevity and neuronal genes identified in our genetic and machine-learning screens. Some of the targeted genes are trans-membrane proteins involved in the neuronal uptake of glutamate in the glutamatergic neurotransmitter signaling. Theanine is an analog of glutamine that can cross the blood-brain barrier, so it has direct effects on the brain. Among its psychoactive properties, L-Theanine is reported to reduce metal stress and improved cognition and mood via its expected binding to the GABA brain receptors in the parasympathetic nervous system. Thus L-Theanine appears to increase the overall level of the brain inhibitory transmitter GABA and is reported to promote alpha wave production in the brain. L-Theanine also affects the expression of Excitatory Amino Acid Transporters (EAATs), which are novel longevity and neuronal target genes identified in our genetic and machine-learning screens. L-Theanine also increases brain dopamine concentrations and has significant affinities for the AMPA, Kainate, and NMDA receptors. The AMPA receptor is a non-NMDA trans-membrane receptor for glutamate that mediates fast synaptic transmission in the central nervous system. Kainate receptors are non-NMDA receptors that respond to the neurotransmitter glutamate, which have been implicated in inhibitory neurotransmission via promoting the release of the inhibitory neurotransmitter GABA. The NMDA receptor is a glutamate receptor and helps control memory and synaptic plasticity. L-Theanine may also have positive effects on serotonin levels. In rats, L-Theanine has been neuroprotective.

14) Genistein is a phytoestrogen isoflavone that binds the Estrogen Receptor, which ia linked to longevity and neuronal function in our genetic and machine learning screens. Genistein also down regulates beta-amyloid, glut-1 and presenilin, which help promote healthy brain function. Genistein is also reported to increase autophagy (the cellular waste system), PPAR, and the Nrf-2 antioxidant response. All of these additional gene functions promote longevity and neural function.

15) Astrogaloside IV is a high-dose purified major active component of Astragalus and is synergistic with the wide spectrum extract of Astragalus membranaceus as our first ingredient. Astragaloside IV is the most potent active ingredient naturally present in astragalus.

16) PQQ also known as Pyrroloquinoline quinone is a small quinone molecule which has the ability to be a REDOX agent, capable of reducing oxidants (an antioxidant effect) and then being recycled by glutathione back into an active form. It appears to be quite stable as it can undergo several thousand cycles before being used up. PQQ seems to modify oxidation in a cell after binding to some proteins, and this modulatory role it plays can alter the signaling processes that go on in a cell.

17) Lithium (as Lithium orotate) is added as an important trace mineral. Lithium promotes several genetic pathways that are important for longevity and neuronal function. For example, lithium promotes NCS-1/Frequenin that codes a calcium-binding protein involved in neurotransmitter release. Other important neural pathways affected by lithium include autophagy, tau phosphorylation, and neural transmitter breakdown by acetylcholinesterase. These are very important pathways for neural function. Lithium has been added at a very low dose, which our testing showed extended longevity while minimizing potential side effects.

18) Vitamin D3 also known as Cholecalciferol is part of a group of fat-soluble secosteroids responsible for increasing intestinal absorption of calcium, magnesium, and phosphate, and multiple other biological effects. In humans, the most important compounds in this group are vitamin D3 (also known as cholecalciferol) and vitamin D2 (ergocalciferol). Vitamin D3 can be ingested from the diet or from supplements and is also produced in the skin when exposed to sunlight. Only a few foods contain vitamin D3. The major natural source of the vitamin is synthesis of cholecalciferol in the skin from cholesterol through a chemical reaction that is dependent on sun exposure (specifically UVB radiation). Dietary recommendations typically assume that all of a person’s vitamin D is taken by mouth, as sun exposure in the population is variable and recommendations about the amount of sun exposure that is safe are uncertain in view of the skin cancer risk.

19) Selenium (as a selenium amino acid complex) promotes major genes involved in longevity and neural function. For example, Selenium promotes the Pre-mRNA-Processing splicing Factor 8 (PRPF8) and Excision Repair Cross-Complementing 1 (ERCC1), which were identified by Genescient as major targets in their genetic pathway studies on longevity and neural function. PRP8 plays an essential role in cellular message processing, while ERCC1 is important for genetic repair. Both these basic processes can decline with age. Selenium is also a cofactor in many selenoproteins, which can help promote aluminum detoxification.

20) and 21) Methyl B-12 and Methyl Folate work together as the active methylated forms of Vitamin B-12 and Folic Acid. The active methylated forms of these essential vitamins are typically not present in food and many people are deficient in the methylated form of Folate or B-12 with age, leading to neurological dysfunction. It has been estimated that some 40% of Americans have only one active gene for converting dietary Folate to the active methyl folate form and 10% of Americans lack both active methyl converting genes. Memex 100+TM provides 600 mcg per day Methyl Folate (5-MTHF) and 500 mcg per day Methyl B-12.

Safety: The ingredients in Memex® 100+ are nutraceutical grade and have been individually tested in both animals and humans without significant safety issues. Those with pre-existing conditions of diabetes or hypertension should coordinate this product with your doctor, as lower blood glucose or reduced blood pressure can result from taking the recommended dose of this product.

Warnings: The supplement is not recommended for pregnant, lactating, or hypoglycemic individuals.

References

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FDA Disclaimer: This product has not been approved by the FDA and is not intended to diagnose, prevent, treat, or cure any disease.

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