Stem Cell Support for Restful Sleep, Stress Reduction, Healthy Adrenals and Healthy Cortisol Levels

Advanced Calm

Advanced Calm Options

The everyday stress of modern life ages us and so does poor sleep. Advanced CalmTM is our patent-pending nutraceutical supplement that helps to support the adrenal system, reduce stress, decrease anxiety, improve sleep, increase energy, and maintain healthy cortisol levels.

Our modern high stress life style can lead to deregulated cortisol cycles, further increasing stress, fatigue, and poor sleep. These problems become even greater as we age and they age us faster. Advanced CalmTM provides help both during the day and night without causing any day time drowsiness.

Developed by experts in the anti-aging field, Advanced CalmTM was created using genetic and computer intelligence systems to select natural substances that support longevity, adult stem cells, and organ health with age.

Promote Better Adrenal Function With the Power of Your Own Stem Cells

All organ systems have their own reservoirs of adult stem cells. Unfortunately, as we are exposed to modern stress and as we age most adult stem cell populations either decline in number and/or lose the ability to differentiate into functional tissue-specific cells. For example, in many critical organs old folks have only half the number of stem cells found in young people. Thus, adult stem cells become more and more dysfunctional, so that organ and tissue dysfunction increases with age.

The Many Benefits of Advanced CalmTM

1. Promotes adult stem cell growth and neurogenesis [1-6] and stem cell factor [7].
2. Improves adrenal function and reduces cortisol levels [2,8-12]
3. Reduces stress and anxiety [3,8-10,12-33]
4. Promotes restful sleep [22,34-47]
5. Promotes cognitive performance and mood [6,30,46,48-53]
6. Fights fatigue and promotes stamina [54-56]
7. May reduce blood pressure for those already in the normal range [26,57-61]
8. May reduce LDL cholesterol for those already in the normal range[62-64] and blood vessel wall thickness [65]
9. May improve sexual function and fertility levels [66-69]
10. May extend lifespan [70,71]
11. Helps promote the immunes system [72,73]

Advanced CalmTM Formulation and Use

Serving Size: One type 00 capsule

Servings Per Container: 60 Capsules

Recommended Use: Typical usage of Advanced CalmTM is one or two capsules per day, preferably just before bed time. Since Advanced CalmTM is a potent formulation, start off with one capsule per day and try taking two capsules per day after 3 or 4 days if you have not experienced significant stress reduction or restful sleep.


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Active Ingredients: There are 8 natural components that make up the patent-pending combination in Advanced CalmTM. The herbal components are highly extracted natural herbs that are standardized for active components that promote adrenal function, adult stem cells, higher quality of sleep, and lower stress:

1) Withania somnifera (aka Ashwagandha) is the principle adaptogen in Indian Ayurvedic Medicine (IAM) that has been shown to reduce chronic stress via modulation of Cortisol and neurotransmitters, which has positive effects on stem cells, telomeres, and the several hormone secreting organs. Unlike American and Asian ginseng adaptogens, Withania has rebalancing and energy promoting effects without raising blood pressure. Life Code? uses a high quality proprietary IAM Withania somnifera extract that tests well in our stem cell screening experiments.

2) Schisandra chinensis berry extract has been important in Chinese traditional medicine as an “adaptogen” for stress resistance, longevity, and increasing energy, physical performance, and endurance. Schisandra extracts reduce TNF-alpha, IL-1B, IL-6, Abeta, and cortisol to suppress neural inflammation. Schisandra also induces the protective Nrf2 and HO-1 genes to promote cholinergic signaling. These pathways are all strongly linked to longevity in our genetic and machine-learning screens and to stress though the current literature.

3) L-Theanine is a natural amino acid from Camellia sinesis that reduces mental stress and inflammation while improving cognition and protecting brain cells from ischemic or toxic injury. L-theanine alters novel longevity and stress genes identified in our genetic and machine-learning screens. Among its psychoactive properties, L-Theanine is reported to reduce metal stress and improved cognition and mood via its expected binding to the GABA brain receptors in the parasympathetic nervous system. Thus L-Theanine appears to increase the overall level of the brain inhibitory transmitter GABA and is reported to promote alpha wave production in the brain. L-Theanine also increases brain dopamine concentrations and has significant affinities for the AMPA, Kainate, and NMDA receptors.

4) Lemon Balm leaves are often used for their calming effects to promote sleep and reduce stress and anxiety. Traditionally, the herb has also been taken for indigestion, infections, mood disorders, menstrual cramps, and blood pressure.

5) Epimedium koreanum aerial parts (aka Horney Goat Weed) act as a general tonic with aphrodisiac effects. The main standardized component in our our Epimedium extract is icariin, which increases blood flow to the body organs by targeting PDE-5 and Nitric Oxide. Epidmedium extracts have often been used to support the immune system and sexual and cognitive performance. Life Code? uses a high quality proprietary Epimedium koreanum extract that tests well in our stem cell screening experiments.

6) Valerian root is most commonly used in combination with Lemon Balm for sleep disorders. This complex herb is calming without the handover of more potent sedatives. Beside its anti-anxiety effects, other uses have included muscle or uterine cramps, and muscle relaxant for pain relief.

7) Magnolia bark is an herb that has been utilized to support healthy cortisol levels while reducing anxiety and stress. It also has benefits for abdominal pain, indigestion, LDL cholesterol, and vascular health.

8) Pregnenolone is a natural hormone that is primarily manufactured by the adrenal glands. Pregnenolone is the precursor for DHEA and Progesterone which are precursors to all other hormones. With age, these hormones often decline with age, leading to lower energy levels and problems with anxiety, cognition, and sleep quality. Pregnenolone supplements can provide needed hormone replacement and is generally available in capsules ranging from 10 mg up to 100 mg. Advanced CalmTM uses very low 3 mg servings of Pregnenolone which is a very conservative amount yet can make a big difference in results compared to other adrenal, cortisol and stress supplements on the market which do not contain any. Even taking the recommended highest dose of Advanced CalmTM only gives 6 mg, which is a little over half of the common 10 mg or higher doses found in normal Pregnenolone supplements. Since Pregnenolone accumulates taking 3 mg – 6 mg per day is a better serving size for long term use.

Safety: The eight components in Advanced CalmTM are nutraceutical grade and have been individually tested in both animals and humans without significant safety issues. Advanced CalmTM is produced using cGMP (Good Manufacturing Practices) in FDA certified production facilities and each batch lot is independently lab tested for harmful microorganisms and toxic metals. This nutraceutical supplement is not recommended for pregnant or lactating women.


1. Takeda A, Sakamoto K, Tamano H, Fukura K, Inui N, et al. (2011) Facilitated neurogenesis in the developing hippocampus after intake of theanine, an amino acid in tea leaves, and object recognition memory. Cell Mol Neurobiol 31: 1079-1088.

2. Yoo DY, Choi JH, Kim W, Yoo KY, Lee CH, et al. (2011) Effects of Melissa officinalis L. (lemon balm) extract on neurogenesis associated with serum corticosterone and GABA in the mouse dentate gyrus. Neurochem Res 36: 250-257.

3. Tang JY, Zeng YS, Chen QG, Qin YJ, Chen SJ, et al. (2008) [Effects of Valerian on the level of 5-hydroxytryptamine, cell proliferation and neurons in cerebral hippocampus of rats with depression induced by chronic mild stress]. Zhong Xi Yi Jie He Xue Bao 6: 283-288.

4. Yang R, Zhou R, Chen L, Cai W, Tomimoto H, et al. (2011) Pregnenolone sulfate enhances survival of adult-generated hippocampal granule cells via sustained presynaptic potentiation. Neuropharmacology 60: 529-541.

5. Mayo W, Lemaire V, Malaterre J, Rodriguez JJ, Cayre M, et al. (2005) Pregnenolone sulfate enhances neurogenesis and PSA-NCAM in young and aged hippocampus. Neurobiol Aging 26: 103-114.

6. Mayo W, George O, Darbra S, Bouyer JJ, Vallee M, et al. (2003) Individual differences in cognitive aging: implication of pregnenolone sulfate. Prog Neurobiol 71: 43-48.

7. Tian H, Huang D, Li T, Huang L, Zheng X, et al. (2015) The protective effects of total phenols in magnolia officinalix rehd. et wils on gastrointestinal tract dysmotility is mainly based on its influence on interstitial cells of cajal. Int J Clin Exp Med 8: 20279-20286.

8. Li J, Wang J, Shao JQ, Du H, Wang YT, et al. (2015) Effect of Schisandra chinensis on interleukins, glucose metabolism, and pituitary-adrenal and gonadal axis in rats under strenuous swimming exercise. Chin J Integr Med 21: 43-48.

9. Chandrasekhar K, Kapoor J, Anishetty S (2012) A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med 34: 255-262.

10. Choudhary D, Bhattacharyya S, Joshi K (2016) Body Weight Management in Adults Under Chronic Stress Through Treatment With Ashwagandha Root Extract: A Double-Blind, Randomized, Placebo-Controlled Trial. J Evid Based Complementary Altern Med.

11. Kalani A, Bahtiyar G, Sacerdote A (2012) Ashwagandha root in the treatment of non-classical adrenal hyperplasia. BMJ Case Rep 2012.

12. Xu Q, Yi LT, Pan Y, Wang X, Li YC, et al. (2008) Antidepressant-like effects of the mixture of honokiol and magnolol from the barks of Magnolia officinalis in stressed rodents. Prog Neuropsychopharmacol Biol Psychiatry 32: 715-725.

13. Kardashev A, Ratner Y, Ritsner MS (2015) Add-on Pregnenolone with L-Theanine to Antipsychotic Therapy Relieves Negative and Anxiety Symptoms of Schizophrenia: An 8-week, randomized, double-blind, placebo-controlled trial. Clin Schizophr Relat Psychoses.

14. White DJ, de Klerk S, Woods W, Gondalia S, Noonan C, et al. (2016) Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial. Nutrients 8.

15. Durg S, Dhadde SB, Vandal R, Shivakumar BS, Charan CS (2015) Withania somnifera (Ashwagandha) in neurobehavioural disorders induced by brain oxidative stress in rodents: a systematic review and meta-analysis. J Pharm Pharmacol 67: 879-899.

16. Pratte MA, Nanavati KB, Young V, Morley CP (2014) An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera). J Altern Complement Med 20: 901-908.

17. E Q, Tang M, Zhang X, Shi Y, Wang D, et al. (2015) Protection of seven dibenzocyclooctadiene lignans from Schisandra chinensis against serum and glucose deprivation injury in SH-SY5Y cells. Cell Biol Int 39: 1418-1424.

18. Li W, Qu XN, Han Y, Zheng SW, Wang J, et al. (2015) Ameliorative effects of 5-hydroxymethyl-2-furfural (5-HMF) from Schisandra chinensis on alcoholic liver oxidative injury in mice. Int J Mol Sci 16: 2446-2457.

19. Li B, Zhu L, Wu T, Zhang J, Jiao X, et al. (2015) Effects of triterpenoid from Schisandra chinensis on oxidative stress in alcohol-induced liver injury in rats. Cell Biochem Biophys 71: 803-811.

20. Pu HJ, Cao YF, He RR, Zhao ZL, Song JH, et al. (2012) Correlation between Antistress and Hepatoprotective Effects of Schisandra Lignans Was Related with Its Antioxidative Actions in Liver Cells. Evid Based Complement Alternat Med 2012: 161062.

21. Kim KJ, Yoon KY, Hong HD, Lee BY (2012) Schisandra chinensis prevents hepatic lipid peroxidation and oxidative stress in rats subjected to heat environmental stress. Phytother Res 26: 1674-1680.

22. Hidese S, Ota M, Wakabayashi C, Noda T, Ozawa H, et al. (2016) Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study. Acta Neuropsychiatr: 1-8.

23. Lu K, Gray MA, Oliver C, Liley DT, Harrison BJ, et al. (2004) The acute effects of L-theanine in comparison with alprazolam on anticipatory anxiety in humans. Hum Psychopharmacol 19: 457-465.

24. Ceremuga TE, Martinson S, Washington J, Revels R, Wojcicki J, et al. (2014) Effects of L-theanine on posttraumatic stress disorder induced changes in rat brain gene expression. ScientificWorldJournal 2014: 419032.

25. Unno K, Tanida N, Ishii N, Yamamoto H, Iguchi K, et al. (2013) Anti-stress effect of theanine on students during pharmacy practice: positive correlation among salivary alpha-amylase activity, trait anxiety and subjective stress. Pharmacol Biochem Behav 111: 128-135.

26. Yoto A, Motoki M, Murao S, Yokogoshi H (2012) Effects of L-theanine or caffeine intake on changes in blood pressure under physical and psychological stresses. J Physiol Anthropol 31: 28.

27. Wise LE, Premaratne ID, Gamage TF, Lichtman AH, Hughes LD, et al. (2012) l-theanine attenuates abstinence signs in morphine-dependent rhesus monkeys and elicits anxiolytic-like activity in mice. Pharmacol Biochem Behav 103: 245-252.

28. Ritsner MS, Miodownik C, Ratner Y, Shleifer T, Mar M, et al. (2011) L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study. J Clin Psychiatry 72: 34-42.

29. Kennedy DO, Little W, Scholey AB (2004) Attenuation of laboratory-induced stress in humans after acute administration of Melissa officinalis (Lemon Balm). Psychosom Med 66: 607-613.

30. Scholey A, Gibbs A, Neale C, Perry N, Ossoukhova A, et al. (2014) Anti-stress effects of lemon balm-containing foods. Nutrients 6: 4805-4821.

31. Mirabi P, Mojab F (2013) The effects of valerian root on hot flashes in menopausal women. Iran J Pharm Res 12: 217-222.

32. Cui W, Wang Y, Chen Q, Sun W, Cai L, et al. (2013) Magnolia extract (BL153) ameliorates kidney damage in a high fat diet-induced obesity mouse model. Oxid Med Cell Longev 2013: 367040.

33. Chuang DY, Chan MH, Zong Y, Sheng W, He Y, et al. (2013) Magnolia polyphenols attenuate oxidative and inflammatory responses in neurons and microglial cells. J Neuroinflammation 10: 15.

34. Zhang C, Mao X, Zhao X, Liu Z, Liu B, et al. (2014) Gomisin N isolated from Schisandra chinensis augments pentobarbital-induced sleep behaviors through the modification of the serotonergic and GABAergic system. Fitoterapia 96: 123-130.

35. Wei B, Li Q, Fan R, Su D, Ou X, et al. (2013) UFLC-MS/MS method for simultaneous determination of six lignans of Schisandra chinensis (Turcz.) Baill. in normal and insomniac rats brain microdialysates and homogenate samples: towards an in-depth study for its sedative-hypnotic activity. J Mass Spectrom 48: 448-458.

36. Ota M, Wakabayashi C, Sato N, Hori H, Hattori K, et al. (2015) Effect of L-theanine on glutamatergic function in patients with schizophrenia. Acta Neuropsychiatr 27: 291-296.

37. Lyon MR, Kapoor MP, Juneja LR (2011) The effects of L-theanine (Suntheanine(R)) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev 16: 348-354.

38. Gromball J, Beschorner F, Wantzen C, Paulsen U, Burkart M (2014) Hyperactivity, concentration difficulties and impulsiveness improve during seven weeks’ treatment with valerian root and lemon balm extracts in primary school children. Phytomedicine 21: 1098-1103.

39. Taavoni S, Nazem Ekbatani N, Haghani H (2013) Valerian/lemon balm use for sleep disorders during menopause. Complement Ther Clin Pract 19: 193-196.
40. Nunes A, Sousa M (2011) [Use of valerian in anxiety and sleep disorders: what is the best evidence?]. Acta Med Port 24 Suppl 4: 961-966.

41. Taavoni S, Ekbatani N, Kashaniyan M, Haghani H (2011) Effect of valerian on sleep quality in postmenopausal women: a randomized placebo-controlled clinical trial. Menopause 18: 951-955.

42. Fernandez-San-Martin MI, Masa-Font R, Palacios-Soler L, Sancho-Gomez P, Calbo-Caldentey C, et al. (2010) Effectiveness of Valerian on insomnia: a meta-analysis of randomized placebo-controlled trials. Sleep Med 11: 505-511.

43. Chen CR, Zhou XZ, Luo YJ, Huang ZL, Urade Y, et al. (2012) Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, induces sleep via the benzodiazepine site of GABA(A) receptor in mice. Neuropharmacology 63: 1191-1199.

44. Ma H, Jo YJ, Ma Y, Hong JT, Kwon BM, et al. (2009) Obovatol isolated from Magnolia obovata enhances pentobarbital-induced sleeping time: Possible involvement of GABAA receptors/chloride channel activation. Phytomedicine 16: 308-313.

45. Darbra S, George O, Bouyer JJ, Piazza PV, Le Moal M, et al. (2004) Sleep-wake states and cortical synchronization control by pregnenolone sulfate into the pedunculopontine nucleus. J Neurosci Res 76: 742-747.

46. Darnaudery M, Bouyer JJ, Pallares M, Le Moal M, Mayo W (1999) The promnesic neurosteroid pregnenolone sulfate increases paradoxical sleep in rats. Brain Res 818: 492-498.

47. Steiger A, Trachsel L, Guldner J, Hemmeter U, Rothe B, et al. (1993) Neurosteroid pregnenolone induces sleep-EEG changes in man compatible with inverse agonistic GABAA-receptor modulation. Brain Res 615: 267-274.

48. Kennedy DO, Wake G, Savelev S, Tildesley NT, Perry EK, et al. (2003) Modulation of mood and cognitive performance following acute administration of single doses of Melissa officinalis (Lemon balm) with human CNS nicotinic and muscarinic receptor-binding properties. Neuropsychopharmacology 28: 1871-1881.

49. Zhang X, Oh M, Kim S, Kim J, Kim H, et al. (2013) Epimediphine, a novel alkaloid from Epimedium koreanum inhibits acetylcholinesterase. Nat Prod Res 27: 1067-1074.

50. Smith CC, Gibbs TT, Farb DH (2014) Pregnenolone sulfate as a modulator of synaptic plasticity. Psychopharmacology (Berl) 231: 3537-3556.

51. Fung LK, Libove RA, Phillips J, Haddad F, Hardan AY (2014) Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. J Autism Dev Disord 44: 2971-2977.

52. Ritsner MS, Bawakny H, Kreinin A (2014) Pregnenolone treatment reduces severity of negative symptoms in recent-onset schizophrenia: an 8-week, double-blind, randomized add-on two-center trial. Psychiatry Clin Neurosci 68: 432-440.

53. Wong P, Chang CC, Marx CE, Caron MG, Wetsel WC, et al. (2012) Pregnenolone rescues schizophrenia-like behavior in dopamine transporter knockout mice. PLoS One 7: e51455.

54. Choudhary B, Shetty A, Langade DG (2015) Efficacy of Ashwagandha (Withania somnifera [L.] Dunal) in improving cardiorespiratory endurance in healthy athletic adults. Ayu 36: 63-68.

55. Biswal BM, Sulaiman SA, Ismail HC, Zakaria H, Musa KI (2013) Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients. Integr Cancer Ther 12: 312-322.

56. Sandhu JS, Shah B, Shenoy S, Chauhan S, Lavekar GS, et al. (2010) Effects of Withania somnifera (Ashwagandha) and Terminalia arjuna (Arjuna) on physical performance and cardiorespiratory endurance in healthy young adults. Int J Ayurveda Res 1: 144-149.

57. Ye BH, Lee SJ, Choi YW, Park SY, Kim CD (2015) Preventive effect of gomisin J from Schisandra chinensis on angiotensin II-induced hypertension via an increased nitric oxide bioavailability. Hypertens Res 38: 169-177.

58. Young Park J, Wook Yun J, Whan Choi Y, Ung Bae J, Won Seo K, et al. (2012) Antihypertensive effect of gomisin A from Schisandra chinensis on angiotensin II-induced hypertension via preservation of nitric oxide bioavailability. Hypertens Res 35: 928-934.

59. Rogers PJ, Smith JE, Heatherley SV, Pleydell-Pearce CW (2008) Time for tea: mood, blood pressure and cognitive performance effects of caffeine and theanine administered alone and together. Psychopharmacology (Berl) 195: 569-577.

60. Yokogoshi H, Kato Y, Sagesaka YM, Takihara-Matsuura T, Kakuda T, et al. (1995) Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats. Biosci Biotechnol Biochem 59: 615-618.

61. Joukar S, Asadipour H, Sheibani M, Najafipour H, Dabiri S (2016) The effects of Melissa officinalis (lemon balm) pretreatment on the resistance of the heart to myocardial injury. Pharm Biol 54: 1005-1013.

62. Jandaghi P, Noroozi M, Ardalani H, Alipour M (2016) Lemon balm: A promising herbal therapy for patients with borderline hyperlipidemia-A randomized double-blind placebo-controlled clinical trial. Complement Ther Med 26: 136-140.

63. Weidner C, Wowro SJ, Freiwald A, Kodelja V, Abdel-Aziz H, et al. (2014) Lemon balm extract causes potent antihyperglycemic and antihyperlipidemic effects in insulin-resistant obese mice. Mol Nutr Food Res 58: 903-907.

64. Chang WC, Yu YM, Hsu YM, Wu CH, Yin PL, et al. (2006) Inhibitory effect of Magnolia officinalis and lovastatin on aortic oxidative stress and apoptosis in hyperlipidemic rabbits. J Cardiovasc Pharmacol 47: 463-468.

65. Chen YL, Lin KF, Shiao MS, Chen YT, Hong CY, et al. (2001) Magnolol, a potent antioxidant from Magnolia officinalis, attenuates intimal thickening and MCP-1 expression after balloon injury of the aorta in cholesterol-fed rabbits. Basic Res Cardiol 96: 353-363.

66. Dongre S, Langade D, Bhattacharyya S (2015) Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Improving Sexual Function in Women: A Pilot Study. Biomed Res Int 2015: 284154.

67. Ambiye VR, Langade D, Dongre S, Aptikar P, Kulkarni M, et al. (2013) Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males: A Pilot Study. Evid Based Complement Alternat Med 2013: 571420.

68. Kang HK, Choi YH, Kwon H, Lee SB, Kim DH, et al. (2012) Estrogenic/antiestrogenic activities of a Epimedium koreanum extract and its major components: in vitro and in vivo studies. Food Chem Toxicol 50: 2751-2759.

69. Makarova MN, Pozharitskaya ON, Shikov AN, Tesakova SV, Makarov VG, et al. (2007) Effect of lipid-based suspension of Epimedium koreanum Nakai extract on sexual behavior in rats. J Ethnopharmacol 114: 412-416.

70. Unno K, Fujitani K, Takamori N, Takabayashi F, Maeda K, et al. (2011) Theanine intake improves the shortened lifespan, cognitive dysfunction and behavioural depression that are induced by chronic psychosocial stress in mice. Free Radic Res 45: 966-974.

71. Zarse K, Jabin S, Ristow M (2012) L-Theanine extends lifespan of adult Caenorhabditis elegans. Eur J Nutr 51: 765-768.

72. Cho WK, Kim H, Choi YJ, Yim NH, Yang HJ, et al. (2012) Epimedium koreanum Nakai Water Extract Exhibits Antiviral Activity against Porcine Epidermic Diarrhea Virus In Vitro and In Vivo. Evid Based Complement Alternat Med 2012: 985151.

73. Cho WK, Weeratunga P, Lee BH, Park JS, Kim CJ, et al. (2015) Epimedium koreanum Nakai displays broad spectrum of antiviral activity in vitro and in vivo by inducing cellular antiviral state. Viruses 7: 352-377.

These statements have not been evaluated by the Food and Drug Administration. Advanced CalmTM is not intended to diagnose, treat, or prevent any disease.

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